Reactome | Dynein drives COPI-independent retrograde traffic from the Golgi to the ER

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Dynein drives COPI-independent retrograde traffic from the Golgi to the ER Show undefined attributes

category	omitted
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10980155
displayName	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER
eventOf	[Pathway:R-CEL-6811436] COPI-independent Golgi-to-ER retrograde traffic - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-8849353] Dynein drives COPI-independent retrograde traffic from the Golgi to the ER - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CEL-8849336] RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [CandidateSet:R-CEL-8849243] BICD dimer [cytosol] [Complex:R-CEL-2029135] Dynein:Dynactin:microtubule [cytosol] [Complex:R-CEL-8849338] RAB6:GTP:COPI-independent retrograde Golgi-to-ER cargo [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-CEL-8849350] RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex - Caenorhabditis elegans
regulatedBy	[PositiveRegulation:R-HSA-8849358] Positive regulation by '2-lysophosphatidylcholine [Golgi membrane]' [PositiveRegulation:10980156] Positive regulation by 'RAB3GAP1:RAB3GAP2:RAB18:GTP [endoplasmic reticulum membrane]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8849353
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-6811436] COPI-independent Golgi-to-ER retrograde traffic
(inferredTo)	[BlackBoxEvent:R-HSA-8849353] Dynein drives COPI-independent retrograde traffic from the Golgi to the ER

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