Reactome | FAICAR => IMP + H2O

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FAICAR => IMP + H2O Show undefined attributes

catalystActivity	[CatalystActivity:10918183] IMP cyclohydrolase activity of ATIC dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10918185
displayName	FAICAR => IMP + H2O
eventOf	[Pathway:R-CEL-73817] Purine ribonucleoside monophosphate biosynthesis - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Caenorhabditis elegans [Reaction:R-CEL-111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - Caenorhabditis elegans [Reaction:R-CEL-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Caenorhabditis elegans [Reaction:R-CEL-111524] IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-73797] FAICAR => IMP + H2O - Homo sapiens
input	[SimpleEntity:R-ALL-111427] FAICAR [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	FAICAR => IMP + H2O 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => IMP + H2O 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O
output	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29602] IMP [cytosol]
precedingEvent	[Reaction:R-CEL-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-73797
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-73817] Purine ribonucleoside monophosphate biosynthesis
(precedingEvent)	[Reaction:R-CEL-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) [Reaction:R-CEL-111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer [Reaction:R-CEL-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] [Reaction:R-CEL-111524] IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]
(inferredTo)	[Reaction:R-HSA-73797] FAICAR => IMP + H2O

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