Reactome | NUDT12 hydrolyses NADH to NMNH

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NUDT12 hydrolyses NADH to NMNH Show undefined attributes

catalystActivity	[CatalystActivity:10978528] NADH pyrophosphatase activity of NUDT12 [peroxisomal matrix]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10978530
displayName	NUDT12 hydrolyses NADH to NMNH
eventOf	[Pathway:R-CEL-196807] Nicotinate metabolism - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6809287] NUDT12 hydrolyses NADH to NMNH - Homo sapiens
input	[SimpleEntity:R-ALL-141343] H2O [peroxisomal matrix] [SimpleEntity:R-ALL-192305] NADH [peroxisomal matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	NUDT12 hydrolyses NADH to NMNH NADH + H2O => reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)
output	[SimpleEntity:R-ALL-389620] AMP [peroxisomal matrix] 2 × [SimpleEntity:R-ALL-193465] H+ [peroxisomal matrix] [SimpleEntity:R-ALL-6809289] NMNH [peroxisomal matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-6809287
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-196807] Nicotinate metabolism
(inferredTo)	[Reaction:R-HSA-6809287] NUDT12 hydrolyses NADH to NMNH

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