Reactome | USP7 deubiquitinates monoubiquitinated PTEN

Schema > Reaction > Entries

USP7 deubiquitinates monoubiquitinated PTEN Show undefined attributes

catalystActivity	[CatalystActivity:10977858] cysteine-type deubiquitinase activity of USP7 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10977860
displayName	USP7 deubiquitinates monoubiquitinated PTEN
eventOf	[Pathway:R-CEL-8948747] Regulation of PTEN localization - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-6807126] Deubiquitinated PTEN translocates to the cytosol - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-6807118] USP7 deubiquitinates monoubiquitinated PTEN - Homo sapiens
input	[EntityWithAccessionedSequence:R-CEL-6807264] daf-18 [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	USP7 deubiquitinates monoubiquitinated PTEN
output	[EntityWithAccessionedSequence:R-CEL-6807273] daf-18 [nucleoplasm] 2 × [DefinedSet:R-CEL-68524] Ub [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-CEL-6807105] Monoubiquitinated PTEN translocates to the nucleus - Caenorhabditis elegans
regulatedBy	[NegativeRegulation:10977861] Negative regulation by 'PML [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-6807118
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-8948747] Regulation of PTEN localization
(precedingEvent)	[Reaction:R-CEL-6807126] Deubiquitinated PTEN translocates to the cytosol
(inferredTo)	[Reaction:R-HSA-6807118] USP7 deubiquitinates monoubiquitinated PTEN

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