Reactome | Regulation of TP53 Activity through Methylation

Schema > Pathway > Entries

created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10995669
displayName	Regulation of TP53 Activity through Methylation
eventOf	[Pathway:R-CEL-5633007] Regulation of TP53 Activity - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:3132571] regulation of signal transduction by p53 class mediator
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CEL-6804266] CHEK2 phosphorylates TTC5 - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-6804760] Regulation of TP53 Activity through Methylation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of TP53 Activity through Methylation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-6804760
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CEL-5633007] Regulation of TP53 Activity
(inferredTo)	[Pathway:R-HSA-6804760] Regulation of TP53 Activity through Methylation

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