Reactome | WIPI2 binds ATG12:ATG5:ATG16L

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WIPI2 binds ATG12:ATG5:ATG16L Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:5679192] phagophore assembly site membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10968810
displayName	WIPI2 binds ATG12:ATG5:ATG16L
eventOf	[Pathway:R-CEL-1632852] Macroautophagy - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-5678490] ATG16L1 complex transfers LC3 from ATG3 to PE - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-5679255] WIPI2 binds ATG12:ATG5:ATG16L - Homo sapiens
input	[Complex:R-CEL-5679262] ATG16L1 complex [cytosol] [Complex:R-CEL-5692947] WIPI2:PI(3,5)P2 [phagophore assembly site membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	WIPI2 binds ATG12:ATG5:ATG16L
output	[Complex:R-CEL-5679367] ATG16L1 complex:WIPI2:PI(3,5)P2 [phagophore assembly site membrane]
precedingEvent	[Reaction:R-CEL-5682012] ATG5:ATG12 binds ATG16L1 - Caenorhabditis elegans [BlackBoxEvent:R-CEL-5682385] The phagophore extends from the PIP3-enriched structure - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-5679255
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-1632852] Macroautophagy
(precedingEvent)	[Reaction:R-CEL-5678490] ATG16L1 complex transfers LC3 from ATG3 to PE
(inferredTo)	[Reaction:R-HSA-5679255] WIPI2 binds ATG12:ATG5:ATG16L