Reactome | DHI and DHICA polymerize forming eumelanin

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DHI and DHICA polymerize forming eumelanin Show undefined attributes

catalystActivity	[CatalystActivity:10967840] catechol oxidase activity of TYR:2xCu2+ [melanosome membrane]
category	omitted
compartment	[Compartment:5668572] melanosome lumen [Compartment:5668575] melanosome membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10967846
displayName	DHI and DHICA polymerize forming eumelanin
eventOf	[Pathway:R-CEL-5662702] Melanin biosynthesis - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-5663050] DHI and DHICA polymerize forming eumelanin - Homo sapiens
input	[DefinedSet:R-ALL-5662708] DHI, DHICA [melanosome lumen] [SimpleEntity:R-ALL-5662695] L-Dopaquinone [melanosome lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	DHI and DHICA polymerize forming eumelanin
output	[Polymer:R-HSA-5662678] Eumelanin [melanosome lumen] [SimpleEntity:R-ALL-5668568] L-Dopa [melanosome lumen]
precedingEvent	[Reaction:R-CEL-5662660] Dopachrome is transformed to DHICA by DCT - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-5663050
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-5662702] Melanin biosynthesis
(inferredTo)	[BlackBoxEvent:R-HSA-5663050] DHI and DHICA polymerize forming eumelanin

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