Reactome | LPIN catalyzes conversion of phosphatidic acid to diacylglycerol

Schema > Reaction > Entries

LPIN catalyzes conversion of phosphatidic acid to diacylglycerol Show undefined attributes

catalystActivity	[CatalystActivity:10964114] phosphatidate phosphatase activity of LPIN [nuclear envelope]
category	transition
compartment	[Compartment:13231] nuclear envelope [Compartment:7660] nucleoplasm
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10964116
displayName	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol
eventOf	[Pathway:R-CEL-4419969] Depolymerization of the Nuclear Lamina - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-5223304] DAG and Ca+2 bind to PKC and tether it to membrane - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-5221130] LPIN catalyzes conversion of phosphatidic acid to diacylglycerol - Homo sapiens
input	[SimpleEntity:R-ALL-5221122] 1,2-diacyl-glycerol 3-phosphate [nuclear envelope] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol 1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate
output	[SimpleEntity:R-ALL-5221124] DAG [nuclear envelope] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm]
precedingEvent	[Reaction:R-CEL-4419948] CTDNEP1:CNEP1R1 dephosphorylates LPIN - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-5221130
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-4419969] Depolymerization of the Nuclear Lamina
(precedingEvent)	[Reaction:R-CEL-5223304] DAG and Ca+2 bind to PKC and tether it to membrane
(inferredTo)	[Reaction:R-HSA-5221130] LPIN catalyzes conversion of phosphatidic acid to diacylglycerol

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