Reactome | phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate

Schema > Reaction > Entries

phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate Show undefined attributes

catalystActivity	[CatalystActivity:10934740] phytanate-CoA ligase activity of SLC27A2 [peroxisomal membrane]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10934742
displayName	phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate
eventOf	[Pathway:R-CEL-389599] Alpha-oxidation of phytanate - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-389639] phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-389622] phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate - Homo sapiens
input	[SimpleEntity:R-ALL-389573] ATP [peroxisomal matrix] [SimpleEntity:R-ALL-193514] CoA-SH [peroxisomal matrix] [SimpleEntity:R-ALL-389596] Phytanate [peroxisomal matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate 3,7,11,15-tetramethylhexadecanoate + ATP + CoA => AMP + diphosphate + phytanoyl-CoA
output	[SimpleEntity:R-ALL-389620] AMP [peroxisomal matrix] [SimpleEntity:R-ALL-389615] Phytanoyl-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-389593] PPi [peroxisomal matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-389622
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-389599] Alpha-oxidation of phytanate
(precedingEvent)	[Reaction:R-CEL-389639] phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2
(inferredTo)	[Reaction:R-HSA-389622] phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate

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