Reactome | Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine

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Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine Show undefined attributes

catalystActivity	[CatalystActivity:10931603] spermidine synthase activity of SRM [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10931605
displayName	Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine
eventOf	[Pathway:R-CEL-351202] Metabolism of polyamines - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-351208] Spermidine => N-acetylated spermidine - Caenorhabditis elegans [Reaction:R-CEL-1237160] MTA is cleaved and phosphorylated - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-351215] Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine - Homo sapiens
input	[SimpleEntity:R-ALL-353113] dc-AdoMet [cytosol] [SimpleEntity:R-ALL-29610] Putrescine [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine S-adenosyl 3-(methylsulfanyl)propylamine + putrescine => S-methyl-5'-thioadenosine + spermidine + H(+)
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-353106] MTAD [cytosol] [SimpleEntity:R-ALL-204635] SPM [cytosol]
precedingEvent	[Reaction:R-CEL-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Caenorhabditis elegans [Reaction:R-CEL-70692] ornithine => putrescine + CO2 - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-351215
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-351202] Metabolism of polyamines
(precedingEvent)	[Reaction:R-CEL-351208] Spermidine => N-acetylated spermidine [Reaction:R-CEL-1237160] MTA is cleaved and phosphorylated
(inferredTo)	[Reaction:R-HSA-351215] Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine

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