Reactome | Constitutive phosphorylation by pERK1/2

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Constitutive phosphorylation by pERK1/2 Show undefined attributes

catalystActivity	[CatalystActivity:10954891] protein serine/threonine kinase activity of p-T,Y MAPK dimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10961086
displayName	Constitutive phosphorylation by pERK1/2
eventOf	[Pathway:R-CEL-3371453] Regulation of HSF1-mediated heat shock response - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3371531] Constitutive phosphorylation by pERK1/2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-CEL-3371452] hsf-1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Constitutive phosphorylation by pERK1/2
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-CEL-4793929] phospho-hsf-1 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-3371531
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-3371453] Regulation of HSF1-mediated heat shock response
(inferredTo)	[Reaction:R-HSA-3371531] Constitutive phosphorylation by pERK1/2

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