Reactome | Oncogene Induced Senescence

Schema > Pathway > Entries

created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10995305
displayName	Oncogene Induced Senescence
eventOf	[Pathway:R-CEL-2559583] Cellular Senescence - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CEL-3209159] Phosphorylated ERF translocates to the cytosol - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-2559585] Oncogene Induced Senescence - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Oncogene Induced Senescence
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-2559585
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CEL-2559583] Cellular Senescence
(hasEncapsulatedEvent)	[Pathway:R-CEL-453279] Mitotic G1 phase and G1/S transition [Pathway:R-CEL-2559580] Oxidative Stress Induced Senescence [Pathway:R-CEL-2559582] Senescence-Associated Secretory Phenotype (SASP) [Pathway:R-CEL-8853884] Transcriptional Regulation by VENTX [Pathway:R-CEL-2559586] DNA Damage/Telomere Stress Induced Senescence
(inferredTo)	[Pathway:R-HSA-2559585] Oncogene Induced Senescence