Reactome | HEXA cleaves the terminal GlcNAc from small HA fragments

Schema > Reaction > Entries

HEXA cleaves the terminal GlcNAc from small HA fragments Show undefined attributes

catalystActivity	[CatalystActivity:10950493] beta-N-acetylhexosaminidase activity of bHEXA [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10956459
displayName	HEXA cleaves the terminal GlcNAc from small HA fragments
eventOf	[Pathway:R-CEL-2160916] Hyaluronan degradation - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-2162226] GUSB tetramer hydrolyzes GlcA-?1,3-GlcNAc - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-2162225] HEXA cleaves the terminal GlcNAc from small HA fragments - Homo sapiens
input	[OtherEntity:R-ALL-2162223] GlcNAc-GlcA-GlcNAc [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	HEXA cleaves the terminal GlcNAc from small HA fragments
output	[SimpleEntity:R-ALL-2162224] GlcA-?1,3-GlcNAc [lysosomal lumen] [SimpleEntity:R-ALL-1678743] GlcNAc [lysosomal lumen]
precedingEvent	[Reaction:R-CEL-2162227] GUSB tetramer hydrolyses (HA)2 - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-2162225
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-2160916] Hyaluronan degradation
(precedingEvent)	[Reaction:R-CEL-2162226] GUSB tetramer hydrolyzes GlcA-?1,3-GlcNAc
(inferredTo)	[Reaction:R-HSA-2162225] HEXA cleaves the terminal GlcNAc from small HA fragments

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