Reactome | Cyclophosphamide is 4-hydroxylated by CYP2B6

Schema > Reaction > Entries

Cyclophosphamide is 4-hydroxylated by CYP2B6 Show undefined attributes

catalystActivity	[CatalystActivity:10930901] monooxygenase activity of Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10930903
displayName	Cyclophosphamide is 4-hydroxylated by CYP2B6
eventOf	[Pathway:R-CEL-211981] Xenobiotics - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-211991] Cyclophosphamide is 4-hydroxylated by CYP2B6 - Homo sapiens
input	[SimpleEntity:R-ALL-211977] CPM [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Cyclophosphamide is 4-hydroxylated by CYP2B6
output	[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-211967] HCPM [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-211991
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-211981] Xenobiotics
(inferredTo)	[Reaction:R-HSA-211991] Cyclophosphamide is 4-hydroxylated by CYP2B6