Reactome | Linoleic acid (LA) metabolism

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Linoleic acid (LA) metabolism Show undefined attributes

compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane [Compartment:17951] peroxisomal matrix [Compartment:17947] peroxisomal membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10995165
displayName	Linoleic acid (LA) metabolism
eventOf	[Pathway:R-CEL-2046104] alpha-linolenic (omega3) and linoleic (omega6) acid metabolism - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:262828] linoleic acid metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CEL-2046098] Activation of linoleic acid to linoleoyl-CoA - Caenorhabditis elegans [Reaction:R-CEL-2046096] Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA - Caenorhabditis elegans [Reaction:R-CEL-2046094] Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA - Caenorhabditis elegans [Reaction:R-CEL-2046092] Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA - Caenorhabditis elegans [Reaction:R-CEL-2046097] Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA - Caenorhabditis elegans [Reaction:R-CEL-2046093] Translocation of tetracosapentaenoyl-CoA to peroxisomes - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-2046105] Linoleic acid (LA) metabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Linoleic acid (LA) metabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-2046105
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-2046104] alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
(inferredTo)	[Pathway:R-HSA-2046105] Linoleic acid (LA) metabolism