Reactome | NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)

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NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) Show undefined attributes

catalystActivity	[CatalystActivity:10780201] [heparan sulfate]-glucosamine N-sulfotransferase activity of NDSTs [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
dbId	10780203
displayName	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
eventOf	[Pathway:R-CEL-2022928] HS-GAG biosynthesis - Caenorhabditis elegans
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CEL-2024108] Some HSPGs are secreted to the plasma membrane - Caenorhabditis elegans
goBiologicalProcess	[GO_BiologicalProcess:19673] heparan sulfate proteoglycan biosynthetic process, enzymatic modification
inferredFrom	[Reaction:R-HSA-2022860] NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) - Homo sapiens
input	[DefinedSet:R-CEL-2076346] Heparan(4)-PGs [Golgi lumen] 2 × [SimpleEntity:R-ALL-741440] PAPS [Golgi lumen]
isInDisease	false
isInferred	true
name	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
output	[DefinedSet:R-CEL-2076452] HS(1)-PGs [Golgi lumen] 2 × [SimpleEntity:R-ALL-742343] PAP [Golgi lumen]
precedingEvent	[Reaction:R-CEL-2022887] NDST1-4 N-deacetylates GlcNAc residues in heparan - Caenorhabditis elegans [Reaction:R-CEL-741449] SLC35B2,3 transport cytosolic PAPS to Golgi lumen - Caenorhabditis elegans
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-2022860
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-2022928] HS-GAG biosynthesis
(precedingEvent)	[BlackBoxEvent:R-CEL-2024108] Some HSPGs are secreted to the plasma membrane
(inferredTo)	[Reaction:R-HSA-2022860] NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)

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