Reactome | Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling

Schema > BlackBoxEvent > Entries

Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling Show undefined attributes

catalystActivity	[CatalystActivity:10924276] ubiquitin-protein transferase activity of Nuclear ubiquitin ligase [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10928295
displayName	Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling
eventOf	[Pathway:R-CEL-201451] Signaling by BMP - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23767] negative regulation of BMP signaling pathway
inferredFrom	[BlackBoxEvent:R-HSA-201425] Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling - Homo sapiens
input	[Complex:R-CEL-201450] p-2S-SMAD1/5/8:SMAD4 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling
precedingEvent	[Reaction:R-CEL-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-201425
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-201451] Signaling by BMP
(inferredTo)	[BlackBoxEvent:R-HSA-201425] Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling

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