Reactome | NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD

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NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD Show undefined attributes

catalystActivity	[CatalystActivity:10928099] nicotinate-nucleotide adenylyltransferase activity of 6xNMNAT1:6xZn2+ [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10928101
displayName	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD
eventOf	[Pathway:R-CEL-196807] Nicotinate metabolism - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-9668967] H+ [nucleoplasm] [SimpleEntity:R-ALL-200492] NAMN [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD beta-nicotinamide D-ribonucleotide + ATP + H(+) => diphosphate + NAD(+) Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1]
output	[SimpleEntity:R-ALL-200499] NAAD [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-200512
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-196807] Nicotinate metabolism
(inferredTo)	[Reaction:R-HSA-200512] NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD

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