Reactome | Glycosaminoglycan-protein linkage region biosynthesis

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Glycosaminoglycan-protein linkage region biosynthesis Show undefined attributes

created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10995145
displayName	Glycosaminoglycan-protein linkage region biosynthesis
eventOf	[Pathway:R-CEL-1630316] Glycosaminoglycan metabolism - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:9939219] glycosaminoglycan-protein linkage region biosynthetic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CEL-8863761] UXS1 tetramer decarboxylates UDP-glucuronate to UDP-xylose - Caenorhabditis elegans [Reaction:R-CEL-1878002] XYLTs transfer Xyl to core protein - Caenorhabditis elegans [Reaction:R-CEL-1889981] B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker - Caenorhabditis elegans [Reaction:R-CEL-1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - Caenorhabditis elegans [Reaction:R-CEL-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-1971475] Glycosaminoglycan-protein linkage region biosynthesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Glycosaminoglycan-protein linkage region biosynthesis A tetrasaccharide linker sequence is required for GAG synthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-1971475
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-1630316] Glycosaminoglycan metabolism
(hasEncapsulatedEvent)	[Pathway:R-CEL-2022928] HS-GAG biosynthesis
(inferredTo)	[Pathway:R-HSA-1971475] Glycosaminoglycan-protein linkage region biosynthesis

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