Reactome | SHC1 events in EGFR signaling

Schema > Pathway > Entries

created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10994185
displayName	SHC1 events in EGFR signaling
eventOf	[Pathway:R-CEL-177929] Signaling by EGFR - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CEL-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-180336] SHC1 events in EGFR signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	SHC1 events in EGFR signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-180336
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CEL-177929] Signaling by EGFR
(inferredTo)	[Pathway:R-HSA-180336] SHC1 events in EGFR signaling

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