Reactome | Synthesis of PIPs at the plasma membrane

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Synthesis of PIPs at the plasma membrane Show undefined attributes

created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10994377
displayName	Synthesis of PIPs at the plasma membrane
eventOf	[Pathway:R-CEL-1483255] PI Metabolism - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20474] phosphatidylinositol biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CEL-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-199456] PTEN dephosphorylates PIP3 - Caenorhabditis elegans [Reaction:R-CEL-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1676145] PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1675994] PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-8870499] PLEKHA3,8 bind PI4P, ARF1 - Caenorhabditis elegans [Reaction:R-CEL-6809309] MTMR6 binds MTMR9 - Caenorhabditis elegans [Reaction:R-CEL-6809254] MTMR8 binds MTMR9 - Caenorhabditis elegans [Reaction:R-CEL-6809325] PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1675810] PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1676134] PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1675836] PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1676203] PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-6809320] PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1675780] PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1675988] PI4P is dephosphorylated to PI by SYNJ at the plasma membrane - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis of PIPs at the plasma membrane
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-1660499
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-1483255] PI Metabolism
(inferredTo)	[Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane

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