Reactome | 1-acyl LPC is acylated to PC by LPCAT

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1-acyl LPC is acylated to PC by LPCAT Show undefined attributes

catalystActivity	[CatalystActivity:10948509] 1-acylglycerol-3-phosphate O-acyltransferase activity of LPCAT [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10948511
displayName	1-acyl LPC is acylated to PC by LPCAT
eventOf	[Pathway:R-CEL-1482788] Acyl chain remodelling of PC - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Caenorhabditis elegans [Reaction:R-CEL-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Caenorhabditis elegans [Reaction:R-CEL-1483186] PC is converted to PS by PTDSS1 - Caenorhabditis elegans [Reaction:R-CEL-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Homo sapiens
input	[SimpleEntity:R-ALL-1524028] 1-acyl LPC [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	1-acyl LPC is acylated to PC by LPCAT
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-CEL-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Caenorhabditis elegans [Reaction:R-CEL-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-1482547
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-1482788] Acyl chain remodelling of PC
(precedingEvent)	[Reaction:R-CEL-1483186] PC is converted to PS by PTDSS1 [Reaction:R-CEL-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] [Reaction:R-CEL-1483182] PC is hydrolyzed to PA and choline by PLD1/2 [Reaction:R-CEL-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6]
(inferredTo)	[Reaction:R-HSA-1482547] 1-acyl LPC is acylated to PC by LPCAT