Reactome | botB HC:LC dimer [extracellular region]

Schema > Complex > Entries

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-CBO-5228681] botB HC:LC dimer:NTNHA:HA [extracellular region] - Clostridium botulinum
consumedByEvent	[Reaction:R-HSA-5244397] botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface - Homo sapiens
created	[InstanceEdit:5228609] D'Eustachio, Peter, 2014-01-14
crossReference	[DatabaseIdentifier:12020820] Mondo:0005498
dbId	5228599
deleted	[Deleted:5251021] Deletion of instance: 181486
disease	[Disease:3632909] botulism
displayName	botB HC:LC dimer [extracellular region]
hasComponent	[EntityWithAccessionedSequence:R-CBO-181507] botB HC disulfide bonded [extracellular region] [Complex:R-CBO-190022] botB LC:Zn2+ disulfide bonded [extracellular region]
inDisease	true
isChimeric	false
literatureReference	[LiteratureReference:181709] Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B
maxDepth	3
modified	[InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08
name	botB HC:LC dimer BoNT/B HC:LC dimer
producedByEvent	[BlackBoxEvent:R-HSA-5228940] Transcytosis and dissociation of botB:NTNHA:HA - Homo sapiens
schemaClass	Complex
species	[Species:168825] Clostridium botulinum
stId	R-CBO-5228599
updateTrackers	[UpdateTracker:9901878] Update Tracker - [Complex:5228599] botB HC:LC dimer [extracellular region] - v75:[addName, updateContainedComponent]

(updatedInstance)	[UpdateTracker:9901878] Update Tracker - [Complex:5228599] botB HC:LC dimer [extracellular region] - v75:[addName, updateContainedComponent]
(replacementInstances)	[Deleted:5251021] Deletion of instance: 181486
(output)	[BlackBoxEvent:R-HSA-5228940] Transcytosis and dissociation of botB:NTNHA:HA
(hasComponent)	[Complex:R-CBO-5228681] botB HC:LC dimer:NTNHA:HA [extracellular region]
(input)	[Reaction:R-HSA-5244397] botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface

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