Reactome | IFI6 binds HSPA5

Schema > Reaction > Entries

category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10440728
displayName	IFI6 binds HSPA5
eventOf	[Pathway:R-BTA-9909505] Modulation of host responses by IFN-stimulated genes - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9921802] IFI6 binds HSPA5 - Homo sapiens
input	[DefinedSet:R-BTA-9921800] ATF6:HSPA5, EIF2AK3:HSPA5 [endoplasmic reticulum membrane] 2 × [EntityWithAccessionedSequence:R-BTA-9921820] IFI6 [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IFI6 binds HSPA5 IFI6 binds BiP
output	[DefinedSet:R-BTA-9927239] IFI6:HSPA5:ATF6, IFI6:HSPA5:EIF2AK3 [endoplasmic reticulum membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9921802
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-9909505] Modulation of host responses by IFN-stimulated genes
(inferredTo)	[Reaction:R-HSA-9921802] IFI6 binds HSPA5