Reactome | Arachidonate is hydroxylated to 18-HETE by CYP(1)

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Arachidonate is hydroxylated to 18-HETE by CYP(1) Show undefined attributes

catalystActivity	[CatalystActivity:10387032] monooxygenase activity of CYP(1) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10440685
displayName	Arachidonate is hydroxylated to 18-HETE by CYP(1)
eventOf	[Pathway:R-BTA-2142816] Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9915993] Arachidonate is hydroxylated to 18-HETE by CYP(1) - Homo sapiens
input	[SimpleEntity:R-ALL-140356] AA [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Arachidonate is hydroxylated to 18-HETE by CYP(1) (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced (NADPH--hemoprotein reductase) => 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
output	[SimpleEntity:R-ALL-2142830] 18-HETE [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-BTA-111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9915993
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2142816] Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
(inferredTo)	[Reaction:R-HSA-9915993] Arachidonate is hydroxylated to 18-HETE by CYP(1)

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