Reactome | Regulation of FXIIa and plasma kallikrein activity

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Regulation of FXIIa and plasma kallikrein activity Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10443514
displayName	Regulation of FXIIa and plasma kallikrein activity
eventOf	[Pathway:R-BTA-9970672] FXIIa activates plasma kallikrein-kinin system - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-BTA-9650473] SERPING1 is secreted - Bos taurus [Reaction:R-BTA-158399] kallikrein binds SERPING1 - Bos taurus [Reaction:R-BTA-158357] factor XIIa binds SERPING1 - Bos taurus [Reaction:R-BTA-9653879] factor XIIa binds HRG - Bos taurus [Reaction:R-BTA-9655840] FXIIa is cleaved to ?-FXIIa - Bos taurus
inferredFrom	[Pathway:R-HSA-9855719] Regulation of FXIIa and plasma kallikrein activity - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of FXIIa and plasma kallikrein activity
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-9855719
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9970672] FXIIa activates plasma kallikrein-kinin system
(inferredTo)	[Pathway:R-HSA-9855719] Regulation of FXIIa and plasma kallikrein activity

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