Reactome | Complement factor I binds to extracellular Factor H:C3b

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Complement factor I binds to extracellular Factor H:C3b Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10372418
displayName	Complement factor I binds to extracellular Factor H:C3b
eventOf	[Pathway:R-BTA-977606] Regulation of Complement cascade - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-976743] Factor I inactivates plasma Factor H-bound C3b - Bos taurus
inferredFrom	[Reaction:R-HSA-976810] Complement factor I binds to extracellular Factor H:C3b - Homo sapiens
input	[Complex:R-BTA-976755] CFH:C3b [extracellular region] [Complex:R-BTA-976749] CFI [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Complement factor I binds to extracellular Factor H:C3b
output	[Complex:R-BTA-976770] CFI:CFH:C3b [extracellular region]
precedingEvent	[Reaction:R-BTA-976768] Factor H binds to C3b - Bos taurus [Reaction:R-BTA-976801] Complement factor I complex formation - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-976810
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-977606] Regulation of Complement cascade
(precedingEvent)	[Reaction:R-BTA-976743] Factor I inactivates plasma Factor H-bound C3b
(inferredTo)	[Reaction:R-HSA-976810] Complement factor I binds to extracellular Factor H:C3b

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