Reactome | KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer

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KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer Show undefined attributes

catalystActivity	[CatalystActivity:10436267] ubiquitin protein ligase activity of p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10436269
displayName	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer
eventOf	[Pathway:R-BTA-9755511] KEAP1-NFE2L2 pathway - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9766687] SESN1,SESN1 bind SQSTM1 and KEAP1 - Bos taurus
inferredFrom	[Reaction:R-HSA-9759172] KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer - Homo sapiens
input	[Complex:R-BTA-9759099] p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] 3 × [DefinedSet:R-BTA-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer
output	[Complex:R-BTA-9766542] ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
precedingEvent	[Reaction:R-BTA-9759169] p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9759172
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9755511] KEAP1-NFE2L2 pathway
(precedingEvent)	[Reaction:R-BTA-9766687] SESN1,SESN1 bind SQSTM1 and KEAP1
(inferredTo)	[Reaction:R-HSA-9759172] KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer

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