Reactome | IKBIP binds IKBKB and CHUK

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IKBIP binds IKBKB and CHUK Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10435932
displayName	IKBIP binds IKBKB and CHUK
eventOf	[Pathway:R-BTA-9758274] Regulation of NF-kappa B signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:162165] negative regulation of canonical NF-kappaB signal transduction
inferredFrom	[Reaction:R-HSA-9749494] IKBIP binds IKBKB and CHUK - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-168104] CHUK [cytosol] [EntityWithAccessionedSequence:R-BTA-9749482] IKBIP [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-BTA-168114] IKBKB [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	IKBIP binds IKBKB and CHUK IKBIP binds IKBKB and IKBKA
output	[Complex:R-BTA-9749465] CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9749494
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9758274] Regulation of NF-kappa B signaling
(inferredTo)	[Reaction:R-HSA-9749494] IKBIP binds IKBKB and CHUK

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