Reactome | GUK1 phosphorylates 6TdGMP to 6TdGDP

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GUK1 phosphorylates 6TdGMP to 6TdGDP Show undefined attributes

catalystActivity	[CatalystActivity:10336956] GMP kinase activity of GUK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10435891
displayName	GUK1 phosphorylates 6TdGMP to 6TdGDP
eventOf	[Pathway:R-BTA-9748787] Azathioprine ADME - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9748969] NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP - Bos taurus
goBiologicalProcess	[GO_BiologicalProcess:8764] xenobiotic metabolic process
inferredFrom	[Reaction:R-HSA-9748963] GUK1 phosphorylates 6TdGMP to 6TdGDP - Homo sapiens
input	[SimpleEntity:R-ALL-9749031] 6TdGMP [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GUK1 phosphorylates 6TdGMP to 6TdGDP 6TdGMP--MPK-->6TdGDP
output	[SimpleEntity:R-ALL-9749033] 6TdGDP [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-BTA-9750555] NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9748963
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9748787] Azathioprine ADME
(inferredTo)	[Reaction:R-HSA-9748963] GUK1 phosphorylates 6TdGMP to 6TdGDP
(precedingEvent)	[Reaction:R-BTA-9748969] NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP

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