Reactome | Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it

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Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it Show undefined attributes

catalystActivity	[CatalystActivity:10341690] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10434942
displayName	Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it
eventOf	[Pathway:R-BTA-456926] Thrombin signalling through proteinase activated receptors (PARs) - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9708859] Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-9708861] F2R [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it
output	[EntityWithAccessionedSequence:R-BTA-114586] F2R [extracellular region] [EntityWithAccessionedSequence:R-BTA-114531] F2R [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9708859
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-456926] Thrombin signalling through proteinase activated receptors (PARs)
(inferredTo)	[Reaction:R-HSA-9708859] Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it

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