Reactome | PDE4A hydrolyses cAMP to AMP

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10434870] 3',5'-cyclic-AMP phosphodiesterase activity of PDE4A [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10434872
displayName	PDE4A hydrolyses cAMP to AMP
eventOf	[Pathway:R-BTA-418555] G alpha (s) signalling events - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9708261] PDE4A hydrolyses cAMP to AMP - Homo sapiens
input	[SimpleEntity:R-ALL-30389] cAMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PDE4A hydrolyses cAMP to AMP
output	[SimpleEntity:R-ALL-76577] AMP [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9708261
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-418555] G alpha (s) signalling events
(inferredTo)	[Reaction:R-HSA-9708261] PDE4A hydrolyses cAMP to AMP

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