Reactome | Hemes:LY96 activates TLR4

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10434838
displayName	Hemes:LY96 activates TLR4
eventOf	[Pathway:R-BTA-9707616] Heme signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9707659] Hemes:LY96 activates TLR4 - Homo sapiens
input	[Complex:R-BTA-9707530] Hemes:LY96 [extracellular region] [EntityWithAccessionedSequence:R-BTA-166045] TLR4 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Hemes:LY96 activates TLR4
output	[Complex:R-BTA-9707678] TLR4:Hemes:LY96 [plasma membrane]
precedingEvent	[Reaction:R-BTA-9707594] Hemes bind LY96 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9707659
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-9707616] Heme signaling
(inferredTo)	[Reaction:R-HSA-9707659] Hemes:LY96 activates TLR4

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