Reactome | Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA

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Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10434717
displayName	Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
eventOf	[Pathway:R-BTA-9607240] FLT3 Signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9706345] Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA - Homo sapiens
input	[Complex:R-BTA-9706284] active FLT3:p-Y GRB10:PIK3R1 [plasma membrane] [EntityWithAccessionedSequence:R-BTA-74787] PIK3CA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
output	[Complex:R-BTA-9706282] active FLT3:p-Y GRB10:PI3K [plasma membrane]
precedingEvent	[Reaction:R-BTA-9706340] Active FLT3:p-Y-GRB10 binds PIK3R1 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9706345
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9607240] FLT3 Signaling
(inferredTo)	[Reaction:R-HSA-9706345] Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA

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