Reactome | SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7

Schema > BlackBoxEvent > Entries

SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 Show undefined attributes

catalystActivity	[CatalystActivity:10434626] ubiquitin protein ligase activity of SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane]
category	omitted
compartment	[Compartment:24337] endocytic vesicle membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10434628
displayName	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
eventOf	[Pathway:R-BTA-9705462] Inactivation of CSF3 (G-CSF) signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-BTA-9707977] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane - Bos taurus
inferredFrom	[BlackBoxEvent:R-HSA-9705738] SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 - Homo sapiens
input	[Complex:R-BTA-9705723] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] [Complex:R-BTA-8953915] Ub:UBE2D1,2,3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
output	[Complex:R-BTA-9707902] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] 2 × [EntityWithAccessionedSequence:R-BTA-180528] CUL5 [cytosol] 2 × [EntityWithAccessionedSequence:R-BTA-180535] ELOC [cytosol] 2 × [EntityWithAccessionedSequence:R-BTA-8863132] RNF7 [cytosol] 2 × [DefinedSet:R-BTA-877267] SOCS-1 and SOCS-3 [cytosol] 2 × [EntityWithAccessionedSequence:R-BTA-180551] TCEB2 [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-9705738
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9705462] Inactivation of CSF3 (G-CSF) signaling
(precedingEvent)	[BlackBoxEvent:R-BTA-9707977] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
(inferredTo)	[BlackBoxEvent:R-HSA-9705738] SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7

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