Reactome | Factor VIIIa dissociates

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Factor VIIIa dissociates Show undefined attributes

category	dissociation
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10433773
displayName	Factor VIIIa dissociates
eventOf	[Pathway:R-BTA-9769739] Regulation of clotting cascade - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1221431] negative regulation of blood coagulation, intrinsic pathway
inferredFrom	[Reaction:R-HSA-9670014] Factor VIIIa dissociates - Homo sapiens
input	[Complex:R-BTA-158307] factor VIIIa [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Factor VIIIa dissociates
output	[EntityWithAccessionedSequence:R-BTA-158199] F8 [extracellular region] [Complex:R-BTA-9670019] factor VIIIa A1:A3-C1-C2 [extracellular region]
precedingEvent	[Reaction:R-BTA-158137] factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9670014
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9769739] Regulation of clotting cascade
(inferredTo)	[Reaction:R-HSA-9670014] Factor VIIIa dissociates