Reactome | RRAGA,B exchanges GDP for GTP

Schema > Reaction > Entries

RRAGA,B exchanges GDP for GTP Show undefined attributes

catalystActivity	[CatalystActivity:10432924] guanyl-nucleotide exchange factor activity of v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane]
category	transition
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10432930
displayName	RRAGA,B exchanges GDP for GTP
eventOf	[Pathway:R-BTA-9639288] Amino acids regulate mTORC1 - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9640168] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine - Bos taurus
inferredFrom	[Reaction:R-HSA-9640167] RRAGA,B exchanges GDP for GTP - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-BTA-9640192] v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	RRAGA,B exchanges GDP for GTP
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-BTA-9639283] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane]
precedingEvent	[Reaction:R-BTA-9640175] v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine - Bos taurus
regulatedBy	[NegativeRegulation:10432931] Negative regulation by 'SH3BP4 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9640167
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9639288] Amino acids regulate mTORC1
(precedingEvent)	[Reaction:R-BTA-9640168] v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine
(inferredTo)	[Reaction:R-HSA-9640167] RRAGA,B exchanges GDP for GTP