Reactome | KICSTOR:GATOR1:GATOR2 [lysosomal membrane]

Schema > Complex > Entries

compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10432911
displayName	KICSTOR:GATOR1:GATOR2 [lysosomal membrane]
hasComponent	[Complex:R-BTA-9638227] GATOR2 [lysosomal membrane] [Complex:R-BTA-9639274] KICSTOR:GATOR1 [lysosomal membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-9639281] KICSTOR:GATOR1:GATOR2 [lysosomal membrane] - Homo sapiens
maxDepth	4
name	KICSTOR:GATOR1:GATOR2
negativelyRegulates	[NegativeRegulation:10432973] Negative regulation by 'KICSTOR:GATOR1:GATOR2 [lysosomal membrane]'
producedByEvent	[BlackBoxEvent:R-BTA-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 - Bos taurus [BlackBoxEvent:R-BTA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Bos taurus [BlackBoxEvent:R-BTA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-9639281
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[BlackBoxEvent:R-BTA-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-BTA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 [BlackBoxEvent:R-BTA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2
(regulator)	[NegativeRegulation:10432973] Negative regulation by 'KICSTOR:GATOR1:GATOR2 [lysosomal membrane]'
(inferredTo)	[Complex:R-HSA-9639281] KICSTOR:GATOR1:GATOR2 [lysosomal membrane]