Reactome | ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA

Schema > Reaction > Entries

ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA Show undefined attributes

catalystActivity	[CatalystActivity:10387012] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX12:Fe2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10431019
displayName	ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA
eventOf	[Pathway:R-BTA-9018677] Biosynthesis of DHA-derived SPMs - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9024997] ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA - Bos taurus [Reaction:R-BTA-9024983] ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA - Bos taurus
inferredFrom	[Reaction:R-HSA-9020274] ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA - Homo sapiens
input	[SimpleEntity:R-ALL-9024011] DHA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA
output	[SimpleEntity:R-ALL-9025012] 14(S)-Hp-DHA [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9020274
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9018677] Biosynthesis of DHA-derived SPMs
(precedingEvent)	[Reaction:R-BTA-9024997] ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA [Reaction:R-BTA-9024983] ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA
(inferredTo)	[Reaction:R-HSA-9020274] ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA