Reactome | GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA

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GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA Show undefined attributes

catalystActivity	[CatalystActivity:10430975] phospholipid-hydroperoxide glutathione peroxidase activity of GPX4-2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10431015
displayName	GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA
eventOf	[Pathway:R-BTA-9020265] Biosynthesis of aspirin-triggered D-series resolvins - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9020259] ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA - Bos taurus [Reaction:R-BTA-9020251] ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA - Bos taurus
inferredFrom	[Reaction:R-HSA-9020271] GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA - Homo sapiens
input	[SimpleEntity:R-ALL-9024522] 17(R)-Hp-DHA [cytosol] 2 × [SimpleEntity:R-ALL-29450] GSH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA
output	[SimpleEntity:R-ALL-9024463] 17(R)-HDHA [cytosol] [SimpleEntity:R-ALL-111745] GSSG [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
precedingEvent	[Reaction:R-BTA-9020261] Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9020271
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9020265] Biosynthesis of aspirin-triggered D-series resolvins
(precedingEvent)	[Reaction:R-BTA-9020259] ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA [Reaction:R-BTA-9020251] ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA
(inferredTo)	[Reaction:R-HSA-9020271] GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA

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