Reactome | IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2

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IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 Show undefined attributes

catalystActivity	[CatalystActivity:10301717] transmembrane receptor protein tyrosine kinase activity of IL26:IL20RA:JAK1:IL10RB:TYK2 [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10203599] Wright, Adam, 2024-03-07
dbId	10301719
displayName	IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2
eventOf	[Pathway:R-BTA-8854691] Interleukin-20 family signaling - Bos taurus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-BTA-8987080] IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 - Bos taurus
inferredFrom	[BlackBoxEvent:R-HSA-8986994] IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-8986478] IL26:IL20RA:JAK1:IL10RB:TYK2 [plasma membrane]
isInDisease	false
isInferred	true
name	IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 JAK1 and TYK2 are phosphorylated by IL26:IL20RA:JAK1:IL10RB:TYK2 receptor complex JAK1 and TYK2 are phosphorylated after il26 il26 receptor interaction
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-8987211] IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 [plasma membrane]
precedingEvent	[Reaction:R-BTA-8986480] IL26:IL20RA:JAK1 binds IL10RB:TYK2 - Bos taurus
releaseDate	2024-03-27
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-8986994
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-8854691] Interleukin-20 family signaling
(precedingEvent)	[BlackBoxEvent:R-BTA-8987080] IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3
(inferredTo)	[BlackBoxEvent:R-HSA-8986994] IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2

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