Reactome | STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex

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STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex Show undefined attributes

catalystActivity	[CatalystActivity:10429128] transmembrane receptor protein kinase activity of IL7R:TSLP:CRLF2:STAT3 [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10429130
displayName	STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex
eventOf	[Pathway:R-BTA-1266695] Interleukin-7 signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-BTA-8983078] p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex - Bos taurus
inferredFrom	[BlackBoxEvent:R-HSA-8983059] STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-8982893] IL7R:TSLP:CRLF2:STAT3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex TSLP:IL7R:CRLF2 phosphorylates STAT3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-8982894] IL7R:TSLP:CRLF2:p-STAT3 [plasma membrane]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48898] Bos taurus
stId	R-BTA-8983059
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1266695] Interleukin-7 signaling
(precedingEvent)	[BlackBoxEvent:R-BTA-8983078] p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex
(inferredTo)	[BlackBoxEvent:R-HSA-8983059] STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex

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