Reactome | KEAP1:NEDD8-CUL3:RBX1 [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-BTA-9759099] p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] - Bos taurus [Complex:R-BTA-8932286] KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] - Bos taurus [Complex:R-BTA-8932286] KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] - Bos taurus
consumedByEvent	[Reaction:R-BTA-9759169] p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10435426
displayName	KEAP1:NEDD8-CUL3:RBX1 [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-BTA-8952516] CUL3 [cytosol] [EntityWithAccessionedSequence:R-BTA-976038] KEAP1 [cytosol] [EntityWithAccessionedSequence:R-BTA-180582] RBX1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-9758078] KEAP1:NEDD8-CUL3:RBX1 [cytosol] - Homo sapiens [Complex:R-HSA-8932333] KEAP1:NEDD8-CUL3:RBX1 [cytosol] - Homo sapiens
maxDepth	2
name	KEAP1:NEDD8-CUL3:RBX1
producedByEvent	[Reaction:R-BTA-9758090] Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation - Bos taurus [Reaction:R-BTA-9758090] Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-8932333
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-BTA-9758090] Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
(hasComponent)	[Complex:R-BTA-8932286] KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] [Complex:R-BTA-9755498] ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] [Complex:R-BTA-9759099] p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] [Complex:R-BTA-9766542] ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(inferredTo)	[Complex:R-HSA-9758078] KEAP1:NEDD8-CUL3:RBX1 [cytosol] [Complex:R-HSA-8932333] KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(input)	[Reaction:R-BTA-9759169] p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1