Reactome | PTPN3 dephosphorylates MAPK12

Schema > Reaction > Entries

PTPN3 dephosphorylates MAPK12 Show undefined attributes

catalystActivity	[CatalystActivity:10422583] protein tyrosine phosphatase activity of PTPN3:p-T183,Y185-MAPK12 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10422585
displayName	PTPN3 dephosphorylates MAPK12
eventOf	[Pathway:R-BTA-5675221] Negative regulation of MAPK pathway - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8867658] PTPN3 dephosphorylates MAPK12 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-BTA-8867651] PTPN3:p-T183,Y185-MAPK12 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PTPN3 dephosphorylates MAPK12
output	[EntityWithAccessionedSequence:R-BTA-171025] MAPK12 [cytosol] 2 × [SimpleEntity:R-ALL-29372] Pi [cytosol] [EntityWithAccessionedSequence:R-BTA-8867650] PTPN3 [cytosol]
precedingEvent	[Reaction:R-BTA-8867654] PTPN3 binds p-T183,Y185 MAPK12 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-8867658
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5675221] Negative regulation of MAPK pathway
(inferredTo)	[Reaction:R-HSA-8867658] PTPN3 dephosphorylates MAPK12

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