Reactome | AP-2 (TFAP2) transcription factors form homo- and heterodimers

Schema > Reaction > Entries

AP-2 (TFAP2) transcription factors form homo- and heterodimers Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10422136
displayName	AP-2 (TFAP2) transcription factors form homo- and heterodimers
eventOf	[Pathway:R-BTA-8866907] Activation of the TFAP2 (AP-2) family of transcription factors - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-8864343] KCTD1 binds TFAP2 homo- and heterodimers - Bos taurus [Reaction:R-BTA-8869568] NPM1 binds TFAP2A homodimer - Bos taurus [Reaction:R-BTA-8864307] TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP - Bos taurus [Reaction:R-BTA-8865265] TFAP2C homodimer binds MYC and KDM5B - Bos taurus [Reaction:R-BTA-8869580] DEK binds TFAP2A homodimers - Bos taurus [Reaction:R-BTA-3234094] SUMOylation of TFAP2C with SUMO1 - Bos taurus
inferredFrom	[Reaction:R-HSA-8864278] AP-2 (TFAP2) transcription factors form homo- and heterodimers - Homo sapiens
input	2 × [CandidateSet:R-BTA-8864286] TFAP2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	AP-2 (TFAP2) transcription factors form homo- and heterodimers
output	[Complex:R-BTA-8864283] TFAP2 homo- and heterodimers [nucleoplasm]
precedingEvent	[Reaction:R-BTA-8864577] TFAP2C translocates to the nucleus - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-8864278
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-BTA-3234094] SUMOylation of TFAP2C with SUMO1 [Reaction:R-BTA-8864343] KCTD1 binds TFAP2 homo- and heterodimers [Reaction:R-BTA-8869568] NPM1 binds TFAP2A homodimer [Reaction:R-BTA-8864307] TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP [Reaction:R-BTA-8865265] TFAP2C homodimer binds MYC and KDM5B [Reaction:R-BTA-8869580] DEK binds TFAP2A homodimers
(hasEvent)	[Pathway:R-BTA-8866907] Activation of the TFAP2 (AP-2) family of transcription factors
(inferredTo)	[Reaction:R-HSA-8864278] AP-2 (TFAP2) transcription factors form homo- and heterodimers