Reactome | Casein kinase II phosphorylates PTEN

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Casein kinase II phosphorylates PTEN Show undefined attributes

catalystActivity	[CatalystActivity:10352158] protein serine/threonine kinase activity of Casein kinase II [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10420198
displayName	Casein kinase II phosphorylates PTEN
eventOf	[Pathway:R-BTA-8948751] Regulation of PTEN stability and activity - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-8850961] PREX2 binds PTEN and inhibits it - Bos taurus
inferredFrom	[Reaction:R-HSA-8850945] Casein kinase II phosphorylates PTEN - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-BTA-199420] PTEN [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Casein kinase II phosphorylates PTEN
output	5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-BTA-8850936] phospho-PTEN [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-8850945
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-8948751] Regulation of PTEN stability and activity
(precedingEvent)	[Reaction:R-BTA-8850961] PREX2 binds PTEN and inhibits it
(inferredTo)	[Reaction:R-HSA-8850945] Casein kinase II phosphorylates PTEN

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