Reactome | Membrane-anchored TNF-? binds TNFR1

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Membrane-anchored TNF-? binds TNFR1 Show undefined attributes

category	dissociation
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10339532
displayName	Membrane-anchored TNF-? binds TNFR1
eventOf	[Pathway:R-BTA-75893] TNF signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-5626988] TNF-?:TNFR1 binds NSMAF - Bos taurus [Reaction:R-BTA-5626953] TNF-?:TNFR1 binds DENN/MADD - Bos taurus [Reaction:R-BTA-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - Bos taurus
inferredFrom	[Reaction:R-HSA-83660] Membrane-anchored TNF-? binds TNFR1 - Homo sapiens
input	[Complex:R-BTA-3371351] TNF(1-233) trimer [plasma membrane] [Complex:R-BTA-5634181] TNFRSF1A:BAG4 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Membrane-anchored TNF-? binds TNFR1
output	3 × [EntityWithAccessionedSequence:R-BTA-5212670] BAG4 [cytosol] [Complex:R-BTA-74277] TNF-?:TNFR1 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-83660
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-75893] TNF signaling
(precedingEvent)	[Reaction:R-BTA-5626988] TNF-?:TNFR1 binds NSMAF [Reaction:R-BTA-5626953] TNF-?:TNFR1 binds DENN/MADD [Reaction:R-BTA-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
(inferredTo)	[Reaction:R-HSA-83660] Membrane-anchored TNF-? binds TNFR1

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