Reactome | The Ligand:GPCR:G12/13 complex dissociates

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The Ligand:GPCR:G12/13 complex dissociates Show undefined attributes

category	dissociation
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10368612
displayName	The Ligand:GPCR:G12/13 complex dissociates
eventOf	[Pathway:R-BTA-416482] G alpha (12/13) signalling events - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-8964274] G alpha (12) binds BTK - Bos taurus [Reaction:R-BTA-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - Bos taurus [Reaction:R-BTA-398184] LARG activation by G alpha 12/13 - Bos taurus [Reaction:R-BTA-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Bos taurus [Reaction:R-BTA-392295] Gbeta:gamma recruits PI3K gamma - Bos taurus [Reaction:R-BTA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane - Bos taurus [Reaction:R-BTA-398040] Gbeta:gamma activation of PLC beta - Bos taurus [Reaction:R-BTA-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex - Bos taurus
inferredFrom	[Reaction:R-HSA-751019] The Ligand:GPCR:G12/13 complex dissociates - Homo sapiens
input	[Complex:R-BTA-751015] Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	The Ligand:GPCR:G12/13 complex dissociates
output	[DefinedSet:R-BTA-418572] G-protein alpha (12/13):GTP [plasma membrane] 2 × [Complex:R-BTA-167434] G-protein beta-gamma complex [plasma membrane] [DefinedSet:R-BTA-791500] GPCRs that activate G12/13 [plasma membrane] [DefinedSet:R-ALL-791498] Ligands of GPCRs that activate G12/13 [extracellular region]
precedingEvent	[Reaction:R-BTA-751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-751019
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-416482] G alpha (12/13) signalling events
(precedingEvent)	[Reaction:R-BTA-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP [Reaction:R-BTA-8964274] G alpha (12) binds BTK [Reaction:R-BTA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Reaction:R-BTA-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex [Reaction:R-BTA-398184] LARG activation by G alpha 12/13 [Reaction:R-BTA-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) [Reaction:R-BTA-392295] Gbeta:gamma recruits PI3K gamma [Reaction:R-BTA-398040] Gbeta:gamma activation of PLC beta
(inferredTo)	[Reaction:R-HSA-751019] The Ligand:GPCR:G12/13 complex dissociates

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