Reactome | XDH oxidizes xanthine to form urate

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XDH oxidizes xanthine to form urate Show undefined attributes

catalystActivity	[CatalystActivity:10337389] xanthine oxidase activity of XDH dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10337391
displayName	XDH oxidizes xanthine to form urate
eventOf	[Pathway:R-BTA-74259] Purine catabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-76031] 2 H2O2 => O2 + 2 H2O - Bos taurus [Reaction:R-BTA-71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O - Bos taurus
inferredFrom	[Reaction:R-HSA-74258] XDH oxidizes xanthine to form urate - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol] [SimpleEntity:R-ALL-30064] XAN [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	XDH oxidizes xanthine to form urate xanthine + O2 + H2O => urate + H2O2
output	[SimpleEntity:R-ALL-29408] H2O2 [cytosol] [SimpleEntity:R-ALL-30034] urate [cytosol]
precedingEvent	[Reaction:R-BTA-74255] Guanine + H2O => Xanthine + NH4+ - Bos taurus [Reaction:R-BTA-74247] XDH oxidizes hypoxanthine to form xanthine - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-74258
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-BTA-76031] 2 H2O2 => O2 + 2 H2O [Reaction:R-BTA-71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O
(hasEvent)	[Pathway:R-BTA-74259] Purine catabolism
(inferredTo)	[Reaction:R-HSA-74258] XDH oxidizes xanthine to form urate

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