Reactome | Carnitine synthesis

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Carnitine synthesis Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10442940
displayName	Carnitine synthesis
eventOf	[Pathway:R-BTA-71291] Metabolism of amino acids and derivatives - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21960] carnitine biosynthetic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-BTA-71241] TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA - Bos taurus [Reaction:R-BTA-71249] SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly - Bos taurus [Reaction:R-BTA-71260] ALDH9A1 tetramer dehydrogenates TEABL to form TEABT - Bos taurus [Reaction:R-BTA-71261] BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA - Bos taurus
inferredFrom	[Pathway:R-HSA-71262] Carnitine synthesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Carnitine synthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-71262
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-71291] Metabolism of amino acids and derivatives
(inferredTo)	[Pathway:R-HSA-71262] Carnitine synthesis